In the city centre, farmers threw hay across the boutique-lined Champs-Elysees Avenue and occupied the lanes headed towards the Place de la Concorde square
The protest was similar to a blockade carried out by Irish farmers in Dublin on Wednesday, although the two events were not coordinated.
Macron, 41, has faced discontent against his social and economic reform agenda across French society.
His government last week announced emergency financing in a failed attempt to head off further hospital strikes and has been locked in negotiations with unions this week over pension reform ahead of nationwide transport strikes on Dec. 5th.
Resentment among farmers has been growing at what they call "agri-bashing", or criticism of agriculture over issues ranging from pesticide use to animal welfare.
Attacks on livestock farms and butcher's shops by vegan activists have caused particular outrage. Longstanding tensions with environmental associations have meanwhile deepened amid debates about banning glyphosate and restricting pesticide use near residential areas.
"We're the new scapegoats. As soon as something goes wrong, it's the farmers' fault," Jean-Yves Bricourt, leader of the main FNSEA union in the administrative department of Aisne, told Reuters. "We're treated like criminals."
Farmers widely blame Macron for rushing to ban glyphosate by 2021, going beyond current European Union policy, although the government has promised exemptions for farms that have no viable alternative.
Macron has also been under pressure from farmers over EU trade deals with Canada and the Mercosur bloc of South American countries, which farming groups say will usher in imports of cheaper agricultural goods produced to lower standards.
France is the largest agricultural producer in the EU and the biggest beneficiary of subsidies under the EU's Common Agricultural Policy.
